Seventeen undescribed heterodimers of meroterpene phenol, psocorylins A-Q, were isolated from the fruits of Psoralea corylifolia. Their another monomeric unit derived from flavonone, chalcone, coumarin and isoflavone, respectively. Psocorylins A-E were rare natural spiroketals with the skeleton of 1,4,8-trioxaspiro[4.5]decane deriving from flavonone, and their plausible biosynthetic pathways were proposed. These structures were established by spectroscopic methods. Their absolute configurations were assigned via single-crystal X-ray diffraction, electronic circular dichroism (ECD) calculations and Rh2(OCOCF3)4-induced ECD spectra. Psocorylins B-E, F, M and Q exhibited potent cytotoxic activities against different kinds of tumor cells with IC50 values less than 10 μM.

中文翻译：

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补骨脂果实中​​分枝萜酚的细胞毒性异二聚体

从 Psoralea corylifolia 的果实中分离出 17 种未描述的 meroterpene 苯酚异二聚体，psocorylins AQ。它们的另一个单体单元分别来自黄酮、查耳酮、香豆素和异黄酮。Psocorylins AE 是一种罕见的天然螺旋缩酮，其骨架为来自黄酮酮的 1,4,8-trioxaspiro[4.5] 癸烷，并提出了其合理的生物合成途径。这些结构是通过光谱方法建立的。它们的绝对构型是通过单晶 X 射线衍射、电子圆二色性 (ECD) 计算和 Rh2(OCOCF3)4 诱导的 ECD 光谱确定的。Psocorylins BE、F、M 和 Q 对不同种类的肿瘤细胞表现出有效的细胞毒活性，IC50 值小于 10 μM。