Adults with Down syndrome have an increased risk for both disordered sleep and Alzheimer's disease (AD). In the general population, disrupted sleep has been linked to beta amyloid accumulation, an early pathophysiologic feature of AD. In this study, the association among sleep, beta amyloid, and measures of AD-related cognitive decline was examined in 47 non-demented adults with Down syndrome (aged 26-56 years). Sleep was measured using actigraphy over 7 nights. Pittsburgh Compound B positron emission tomography was used to assess global and striatal beta amyloid burden. Participants had the following clinical AD status: 7 (15%) mild cognitive impairment and 40 (85%) cognitively unaffected. Average length of night-time awakenings was significantly positively associated with striatal beta amyloid and decreased cognitive performance in executive functioning and motor planning and coordination. Findings suggest that disrupted sleep is associated with beta amyloid accumulation and cognitive features of preclinical AD in Down syndrome. Early identification and treatment of sleep problems could be a lifestyle intervention that may delay beta amyloid accumulation and cognitive decline in this AD vulnerable group.

中文翻译：

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唐氏综合症成人睡眠与认知和 β-淀粉样蛋白积聚的关系

患有唐氏综合症的成年人患睡眠障碍和阿尔茨海默病 (AD) 的风险增加。在一般人群中，睡眠中断与 β 淀粉样蛋白积聚有关，这是 AD 的早期病理生理学特征。在这项研究中，在 47 名患有唐氏综合症（年龄 26-56 岁）的非痴呆成人中检查了睡眠、β 淀粉样蛋白和 AD 相关认知衰退措施之间的关联。使用 7 晚的体动记录仪测量睡眠。匹兹堡化合物 B 正电子发射断层扫描用于评估整体和纹状体 β 淀粉样蛋白负荷。参与者具有以下临床 AD 状态：7 名 (15%) 轻度认知障碍和 40 名 (85%) 认知未受影响。夜间觉醒的平均时长与纹状体 β 淀粉样蛋白呈显着正相关，并降低了执行功能和运动计划与协调方面的认知能力。研究结果表明，睡眠中断与唐氏综合症临床前 AD 的 β 淀粉样蛋白积累和认知特征有关。早期识别和治疗睡眠问题可能是一种生活方式干预，可以延缓 AD 易感人群的 β 淀粉样蛋白积累和认知能力下降。