Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p < 0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition.

中文翻译：

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路易体痴呆患者的前脑电图减慢：一项多中心欧洲队列研究

与阿尔茨海默病 (AD) 相比，脑电图 (EEG) 在后部推导中以前阿尔法显性频率 (DF) 减慢是路易体 (DLB) 痴呆症诊断的生物标志物。然而，对原始数据的内部重新评估有助于识别 EEG DLB 生物标志物，表明 DF 在前部推导中比后推导慢。我们假设这种 DF 减慢的前后梯度可能在 DLB 中由丘脑皮质节律失常引起，不同地涉及前后皮质区域，并与认知障碍（小型精神状态检查）相关。来自欧洲 DLB 联盟的 7 个中心的 144 个 DLB、116 个 AD 和 65 个对照中记录了 EEG。光谱分为delta、theta、prealpha、alpha频段。在 DLB 中，平均 DF 在前部和后部都是 prealpha，但前部较低（p < 0.001）。在 14% 的 DLB 中，DF 前部为 prealpha，而后部为 alpha。在 AD 和对照中，DF 始终是 alpha。DLB 中的 EEG 减慢与认知障碍相关。丘脑皮质节律失常引起具有前后梯度的前阿尔法节律，并与认知受损相关。