Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia.,CNS Neuroscience & Therapeutics

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Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia.
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2020-04-28 , DOI: 10.1111/cns.13384
Jia Li ₁ , Jia-Huan Hao ₁ , Di Yao ₁ , Rong Li ₁ , Xue-Fei Li ₁ , Zhi-Yuan Yu ₁ , Xiang Luo ₁ , Xing-Hua Liu ₂ , Ming-Huan Wang ₁ , Wei Wang _{1,

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Affiliation

The involvement of pyroptosis in ischemic stroke remains to be established. Therefore, we used the specific pyroptosis inhibitor Vx765 as an experimental intervention target in a murine model of stroke.

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