Recent Genome Wide Association Studies have identified a number of HLA alleles that are associated with either increased or decreased risk in Follicular Lymphoma. We report a case-control pilot study that aims to validate these studies in a WA population of Follicular Lymphoma patients compared to a control population derived from the Busselton Healthy Ageing Study. We have corroborated the findings of others in demonstrating a significant association of the HLA-DQB1*05:01 risk allele in Follicular Lymphoma cases. We do not report any significant changes associated with the protective alleles that have been previously described. These data are discussed with respect to possible mechanisms for HLA associations in Follicular Lymphoma pathogenesis. This article is protected by copyright. All rights reserved.

中文翻译：

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在澳大利亚数据集中将HLA关联与滤泡性淋巴瘤相关：一项先导研究。

最近的基因组广泛关联研究已经确定了许多与滤泡性淋巴瘤的风险增加或降低相关的HLA等位基因。我们报道了一项病例对照试验研究，旨在与滤网淋巴瘤患者的西澳人群相比，从巴瑟尔顿健康老龄化研究获得的对照人群来验证这些研究。我们证明了滤泡性淋巴瘤病例中HLA-DQB1 * 05：01风险等位基因的显着相关性，证实了其他人的发现。我们没有报告与先前描述的保护性等位基因相关的任何重大变化。关于滤泡性淋巴瘤发病机制中HLA关联的可能机制讨论了这些数据。本文受版权保护。版权所有。