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Two Diterpene Synthases from Chryseobacterium: Chryseodiene Synthase and Wanjudiene Synthase.
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2020-04-28 , DOI: 10.1002/anie.202004691
Lukas Lauterbach 1 , Bernd Goldfuss 2 , Jeroen S Dickschat 1
Affiliation  

Two bacterial diterpene synthases (DTSs) from Chryseobacterium were characterised. The first enzyme yielded the new compound chryseodiene that closely resembles the known fusicoccane diterpenes from fungi, but its experimentally and computationally studied cyclisation mechanism is fundamentally different to the mechanism of fusicoccadiene synthase. The second enzyme produced wanjudiene, a diterpene hydrocarbon with a new skeleton, besides traces of the enantiomer of bonnadiene that was recently discovered from Allokutzneria albata .

中文翻译:

来自金黄杆菌的两种二萜合酶:Chryseodiene Synthase 和 Wanjudiene Synthase。

表征了来自金黄杆菌的两种细菌二萜合酶 (DTS) 。第一种酶产生的新化合物 chryseodiene 与已知的来自真菌的 Fusicoccane 二萜非常相似,但其实验和计算研究的环化机制与 Fusicoccadiene 合酶的机制根本不同。除了最近从Allokutzneria albata 中发现的bonnadiene对映异构体的痕迹外,第二种酶还产生了 wanjudiene,一种具有新骨架的二萜烃。
更新日期:2020-07-06
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