ABSTRACT

Much attention has been recently given to the effect of diet compounds on physical and mental health. Gallic acid is a phenolic compound with antioxidant activity. This compound is widely presented in black tea leaves, green tea, apples, grapes, strawberries, and pineapples. During the past years, it has been reported that gallic acid is effective against nervous system’s disorders including Alzheimer’s disease, Parkinson’s disease, ischemia, and reperfusion, depression and anxiety. These indicate that gallic acid can be considered as a valuable agent for nutraceutical interventions. In this study, several clinical studies suggested that gallic acid can improve human health by preventing or delaying the onset of neurological diseases. The present study indicated the neuroprotective features of gallic acid including the pre-clinical evidence for its effects in AD and PD and other diseases related to the nervous system. Significant efforts are required to confirm the neuroprotective effects of gallic acid in treating the diseases related to the nervous system.

摘要

最近，人们对饮食化合物对身心健康的影响给予了极大关注。没食子酸是具有抗氧化活性的酚类化合物。该化合物广泛存在于黑茶叶，绿茶，苹果，葡萄，草莓和菠萝中。在过去的几年中，已经报道了没食子酸对神经系统疾病有效，包括阿尔茨海默氏病，帕金森氏病，局部缺血以及再灌注，抑郁和焦虑。这些表明没食子酸可以被认为是营养干预的有价值的药物。在这项研究中，一些临床研究表明，没食子酸可以通过预防或延迟神经系统疾病的发作来改善人类健康。本研究表明了没食子酸的神经保护功能，包括其在AD和PD以及其他与神经系统有关的疾病中的作用的临床前证据。为了确认没食子酸在治疗与神经系统有关的疾病中的神经保护作用，需要付出巨大的努力。