A diversity-oriented synthesis (DOS) approach has been used to functionalize 17-ethynyl-17-hydroxysteroids through a one-pot procedure involving a ring-closing enyne metathesis (RCEYM) and a Diels–Alder reaction on the resulting diene, under microwave irradiations. Taking advantage of the propargyl alcohol moiety present on commercially available steroids, this classical strategy was applied to mestranol and lynestrenol, giving a collection of new complex 17-spirosteroids.

中文翻译：

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面向多样性的17螺类固醇合成。

面向多样性的合成（DOS）方法已被用于通过一锅法将17-乙炔基-17-羟基类固醇官能化，该方法包括在微波下进行的闭环烯炔复分解（RCEYM）和生成的二烯上的Diels-Alder反应辐射。利用市场上可买到的类固醇中存在的炔丙醇部分，将这种经典策略应用于甲雌醇和炔雌醇，得到了一系列新的复杂的17-螺类固醇。