Abstract

Transcranial direct current stimulation (tDCS) can sometimes cause the opposite of its intended effect. These reverse effects may be related in part to individual differences in personality and neurochemistry. Previous studies have demonstrated that dopamine levels can impact the effects of tDCS. In the present study, 124 healthy participants took the UPPS impulsive behavior scale. Participants then underwent a single, randomized anodal or sham tDCS session on the prefrontal cortex. While the effects of tDCS were still active, they performed the Stop Signal Task, a measure of state impulsivity. tDCS was associated with increased errors on this task in people who had higher scores on the UPPS in two facets of impulsivity that correlate with dopamine levels. tDCS had no effects on people who are low in trait impulsivity. These results suggest that the reverse effects of tDCS could be associated with inter-individual differences in personality and neurochemistry.

中文翻译：

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当大脑刺激适得其反时：前额叶皮层刺激对冲动的影响

摘要

经颅直流电刺激 (tDCS) 有时会导致与其预期效果相反的效果。这些反向效应可能部分与个性和神经化学的个体差异有关。以前的研究表明，多巴胺水平会影响 tDCS 的效果。在本研究中，124 名健康参与者参加了 UPPS 冲动行为量表。然后，参与者在前额叶皮层接受了一次随机的阳极或假 tDCS 会议。虽然 tDCS 的影响仍然有效，但他们执行了停止信号任务，这是一种状态冲动的测量。tDCS 与在与多巴胺水平相关的两个冲动方面的 UPPS 得分较高的人在这项任务中的错误增加有关。tDCS 对特质冲动性低的人没有影响。