OBJECTIVES We aim to investigate the dentin tubule occlusion and remineralization potential of a novel nano-monetite hydrosol (nMH). METHODS First, nano-monetite hydrosol (nMH) was fabricated by homogeneous precipitation method. Then, the effectiveness of toothpaste with nMH on improving remineralization was evaluated by the measurement of tubule occluding ratio and acid-resistant stability compared with dentifrices comprising nano-hydroxyapatite hydrosol (nHH) and bioactive glass (BG). To explain this result, we studied the ions releasing and remineralization based on gelatin scaffold among nMH, nHH and BG. Finally, the cytotoxicity of these three minerals on Human dental pulp stem cells (HDPSCs) was evaluated. RESULTS Processing for more than 7 days, the toothpaste containing nMH exhibited the significant remineralization potential and acid-resistant compared with two commercial de-sensitive dentifrices comprising nHH and BG. In addition, cytotoxicity test resulted that nMH has good cell compatibility to HDPSCs below extracts concentration of 3.12mg/mL. SIGNIFICANCE Small size, the release of Ca2+ and PO43- with high concentration, strongly binding on dental surface, and fast transformation to HAp, were all needed in the preparation of effective dentin tubule occluding biomaterials.

中文翻译：

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纳米沸石水溶胶对牙本质再矿化和肾小管阻塞的增强作用。

目的我们旨在研究一种新型的纳米透纳水溶胶（nMH）的牙本质小管阻塞和再矿化潜力。方法首先，采用均相沉淀法制备纳米级水溶质溶胶（nMH）。然后，与包含纳米羟基磷灰石水溶胶（nHH）和生物活性玻璃（BG）的洁牙剂相比，通过测量小管阻塞率和耐酸稳定性，评估了使用nMH牙膏改善再矿质的效果。为了解释这一结果，我们研究了基于明胶支架在nMH，nHH和BG中释放和再矿化的离子。最后，评估了这三种矿物质对人牙髓干细胞（HDPSC）的细胞毒性。结果处理超过7天，与包含nHH和BG的两种商业脱敏牙膏相比，含有nMH的牙膏具有显着的再矿化潜力和耐酸性。此外，细胞毒性测试表明，在提取物浓度低于3.12mg / mL时，nMH对HDPSC具有良好的细胞相容性。意义在制备有效的牙本质小管阻塞生物材料时，都需要小尺寸，高浓度Ca2 +和PO43-的释放，在牙齿表面牢固结合以及快速转化为HAp。