Macrophages are immune myeloid cells with an extreme ability to modulate their phenotype in response to insults and/or pathogens. The immunomodulatory capacity of macrophages is also patent during development as they adapt their phenotype to the host tissue environment establishing the heterogeneous populations of tissue-resident macrophages. An important mechanism of immunomodulation in macrophages occurs through the regulation of transcriptional activity. Numerous transcription factors are associated with macrophage plasticity, among them, several nuclear receptors. The nuclear receptors Liver X Receptors (LXRα and LXRβ) have also revealed as active players during macrophage adaptations in diverse scenarios. This review will address the different mechanisms by which LXRs contribute to immunomodulation in macrophages by connecting lipid metabolism and immunity through transcriptional regulation.

中文翻译：

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脂质代谢作为巨噬细胞免疫调节机制：肝脏 X 受体的作用。

巨噬细胞是免疫骨髓细胞，具有调节其表型以响应损伤和/或病原体的极端能力。巨噬细胞的免疫调节能力在开发过程中也是专利的，因为它们使它们的表型适应宿主组织环境，从而建立了组织驻留巨噬细胞的异质种群。巨噬细胞免疫调节的一个重要机制是通过调节转录活性来实现的。许多转录因子与巨噬细胞的可塑性有关，其中包括几种核受体。核受体肝 X 受体（LXRα 和 LXRβ）也在不同情况下的巨噬细胞适应过程中发挥了积极作用。