Phthalates and environmental phenols might be associated with some benign diseases that have been found to be hormone-sensitive. Current knowledge on adverse effects of these chemicals among reproductive women is limited and often controversial. Therefore, the purpose of this study was to investigate the association between the urinary concentration of phthalates and environmental phenols and gynecological disorders from 512 women of reproductive age. The association between chemical concentration and disease in the control and case groups was statistically determined with the questionnaire survey data and measurements using the LC-MS/MS. The results have shown that DEHP metabolites, ethyl paraben and 3,4-DHB showed significant direct associations with leiomyoma and benign ovarian tumors (p < 0.05). We found statistically significant positive relationships between exposure to chemicals (some DEHP metabolites, DHB) and prevalence of gynecologic disorders (p < 0.05). Furthermore, the ORs for leiomyoma associated with these compounds in always user for personal care products (PCPs) was higher than those of sometimes user. High levels of urinary concentrations of these compounds such as DEHP metabolites and parabens and their metabolites showed significant associations with leiomyoma and benign ovarian tumors.

中文翻译：

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邻苯二甲酸盐和环境酚暴露与妇科疾病的关系。

邻苯二甲酸盐和环境酚可能与某些对激素敏感的良性疾病有关。目前关于这些化学物质对生殖妇女的不利影响的知识是有限的，而且经常引起争议。因此，本研究的目的是调查512名育龄妇女的邻苯二甲酸盐尿浓度与环境酚和妇科疾病之间的关系。对照组和病例组中化学物浓度与疾病之间的关联通过问卷调查数据和使用LC-MS / MS的测量值进行统计确定。结果表明，DEHP代谢产物，对羟基苯甲酸乙酯和3,4-DHB与平滑肌瘤和卵巢良性肿瘤具有显着的直接相关性（p <0.05）。我们发现暴露于化学物质（某些DEHP代谢产物，DHB）与妇科疾病的患病率之间存在统计学上的显着正相关（p <0.05）。此外，始终使用个人护理产品（PCP）的与这些化合物相关的平滑肌瘤的OR高于有时使用的那些。这些化合物（例如DEHP代谢物和对羟基苯甲酸酯及其代谢物）的尿液浓度高，表明与平滑肌瘤和卵巢良性肿瘤密切相关。