Clinical trials of oral penicillin preparations in the United States for treating Lyme disease patients with erythema migrans are limited to 2 studies. The results of these studies demonstrated a less than optimal outcome of this treatment. However, there were serious methodologic concerns in both studies precluding the interpretation that phenoxymethylpenicillin specifically should be regarded as ineffective. Therefore, additional clinical trials should be conducted in the United States with close attention to the dose and duration of treatment that have been used very successfully in Europe.

中文翻译：

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在美国评估口服青霉素在治疗莱姆病和偏头痛性红斑患者中的作用。

在美国，口服青霉素制剂治疗偏头痛性红斑的莱姆病患者的临床试验仅限于两项研究。这些研究的结果表明，这种治疗的效果并不理想。但是，在两项研究中均存在严重的方法学问题，排除了将苯氧基甲基青霉素视为无效的解释。因此，应在美国进行更多的临床试验，并密切注意在欧洲非常成功使用的治疗剂量和疗程。