Abstract A mesomeric form of quaternary indoloquinazoline alkaloid, soyauxinium chloride (1) was obtained through the chemical investigation of stem bark and roots of Araliopsis soyauxii Engl. [syn. Vepris soyauxii (Engl.) Mziray] (Rutaceae) together with fifteen known compounds, including three furoquinoline alkaloids, three 2-quinolones, two limonoids, two triterpenes, two steroids, a coumarin, an acridone alkaloid, and a flavonoid glycoside. Their structures were established by comprehensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-HR-MS) and by comparison with previously reported data. 13C NMR data of araliopsinine are also reported here for the first time. The isolated compounds were screened in vitro for their effects on the viability of two different human cancer cell lines, namely prostate PC-3 adenocarcinoma cells and colorectal HT-29 adenocarcinoma cells. However, none of the tested compounds exhibited strong anti-proliferative or cytotoxic activities, to either prostate PC-3 cells or colon HT-29 cells. At 100 μM, the furoquinoline maculine showed a slightly increased anti-proliferative effect, however, exclusively on HT-29 cells. The chemotaxonomic significance of the isolated compounds has also been discussed.

中文翻译：

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来自喀麦隆芸香科 Araliopsis soyauxii Engl 的四元吲哚喹唑啉生物碱和其他成分的中间体形式。

摘要 通过对Araliopsis soyauxii Engl 的茎皮和根的化学研究，获得了季吲哚喹唑啉生物碱的中间体形式，soyauxinium chloride (1)。[同义词。Vepris soyauxii (Engl.) Mziray]（芸香科）以及十五种已知化合物，包括三种呋喃喹啉生物碱、三种 2-喹诺酮、两种柠檬苦素、两种三萜、两种类固醇、一种香豆素、一种吖啶酮生物碱和一种黄酮苷。它们的结构是通过综合光谱和光谱分析（1D 和 2D NMR、ESI-HR-MS）并通过与先前报告的数据进行比较来确定的。araliopsinine 的 13C NMR 数据也是首次报道。在体外筛选分离的化合物对两种不同人类癌细胞系的活力的影响，即前列腺PC-3腺癌细胞和结肠直肠HT-29腺癌细胞。然而，没有一种测试化合物对前列腺 PC-3 细胞或结肠 HT-29 细胞表现出强烈的抗增殖或细胞毒性活性。在 100 μM 时，呋喃喹啉 maculine 显示出略微增强的抗增殖作用，但仅对 HT-29 细胞起作用。还讨论了分离化合物的化学分类学意义。