Annual Review of Immunology ( IF 29.7 ) Pub Date : 2020-04-27 Kathryn E. Stephenson, Kshitij Wagh, Bette Korber, Dan H. Barouch
Development of improved approaches for HIV-1 prevention will likely be required for a durable end to the global AIDS pandemic. Recent advances in preclinical studies and early phase clinical trials offer renewed promise for immunologic strategies for blocking acquisition of HIV-1 infection. Clinical trials are currently underway to evaluate the efficacy of two vaccine candidates and a broadly neutralizing antibody (bNAb) to prevent HIV-1 infection in humans. However, the vast diversity of HIV-1 is a major challenge for both active and passive immunization. Here we review current immunologic strategies for HIV-1 prevention, with a focus on current and next-generation vaccines and bNAbs.
中文翻译:
预防HIV-1的疫苗和广泛中和的抗体
为了持久地结束全球艾滋病大流行,可能需要开发改进的预防HIV-1的方法。临床前研究和早期临床试验的最新进展为阻断HIV-1感染获得的免疫学策略提供了新的希望。目前正在进行临床试验,以评估两种候选疫苗和一种广泛中和的抗体(bNAb)预防人类HIV-1感染的功效。但是,HIV-1的多样性是主动和被动免疫的主要挑战。在这里,我们将回顾当前预防HIV-1的免疫策略,重点是当前和下一代疫苗和bNAb。