In this paper, correlation analysis of protein and mRNA levels in the soil dwelling bacteria Streptomyces coelicolor (S. coelicolor M145) is presented during development of the population as it grew in liquid medium using three biological and two technical replicates, measured during exponential growth, and its entry into the stationary phase. The proteome synthesis time series are compared with the gene expression time series measured previously under identical experimental conditions. Results reveal that about one third of protein/mRNA synthesis profiles are well correlated while another third are correlated negatively. Functional analysis of the highly correlated groups is presented. Based on numerical simulation, the negative correlation between protein and mRNA is shown to be caused by the difference between the rate of translation and protein degradation.

中文翻译：

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土壤寄居原核生物（S. coelicolor）发育过程中蛋白质和mRNA表达的比较。

本文对土壤寄居细菌天蓝色链霉菌（S. coelicolor）中蛋白质和mRNA水平的相关性进行了分析。M145）是在种群发育过程中呈现的，它在液体培养基中生长，使用了三种生物学方法和两种技术重复方法，在指数生长期间进行了测量，并进入了稳定期。将蛋白质组合成时间序列与先前在相同实验条件下测得的基因表达时间序列进行比较。结果显示，大约三分之一的蛋白质/ mRNA合成谱相关性良好，而另一三分之一则呈负相关。介绍了高度相关的群体的功能分析。基于数值模拟，蛋白质和mRNA之间的负相关被证明是由翻译速率和蛋白质降解之间的差异引起的。