当前位置: X-MOL 学术DNA Repair › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.
DNA Repair ( IF 3.8 ) Pub Date : 2020-04-27 , DOI: 10.1016/j.dnarep.2020.102860
Maria Beecher 1 , Namrata Kumar 2 , Sunbok Jang 3 , Vesna Rapić-Otrin 4 , Bennett Van Houten 5
Affiliation  

UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are associated with xeroderma pigmentosum complementation group E. UV-DDB forms a ubiquitin E3 ligase complex with cullin-4A and RBX that helps to relax chromatin around UV-induced photoproducts through the ubiquitination of histone H2A. After providing a brief historical perspective on UV-DDB, we review our current knowledge of the structure and function of this intriguing repair protein. Finally, this article discusses emerging data suggesting that UV-DDB may have other non-canonical roles in base excision repair and the etiology of cancer.



中文翻译:

扩展 UV-DDB 的分子作用:揭示基因组稳定性和癌症。

紫外线损伤的 DNA 结合蛋白 (UV-DDB) 是一种异二聚体复合物,由 DDB1 和 DDB2 组成,参与全球基因组核苷酸切除修复。DDB2中的突变与色素性干皮病互补组 E 相关。UV-DDB 与 cullin-4A 和 RBX 形成泛素 E3 连接酶复合物,通过组蛋白 H2A 的泛素化帮助松弛紫外线诱导的光产物周围的染色质。在简要介绍了 UV-DDB 的历史观点之后,我们回顾了我们目前对这种有趣的修复蛋白的结构和功能的了解。最后,本文讨论了新出现的数据,这些数据表明 UV-DDB 可能在碱基切除修复和癌症病因学中具有其他非规范作用。

更新日期:2020-04-27
down
wechat
bug