Background

Tocopherol isoforms may regulate child lung growth and spirometric measures.

Objective

Our aim was to determine the extent to which plasma α-tocopherol (α-T) or γ-tocopherol (γ-T) isoform levels in early childhood or in utero are associated with childhood lung function.

Methods

We included 622 participants in the Project Viva cohort who had lung function at a mid-childhood visit (age 6-10 years). Maternal and child tocopherol isoform levels were measured by HPLC at the second trimester and 3 years of age, respectively. Multivariable linear regression models (adjusted for mid-childhood body mass index z scores, maternal education, smoking in pregnancy, and prenatal particulate matter with diameter of <2.5 micrometers (PM_2.5) particulate exposure) stratified by tertiles of child γ-T level were used to assess the association of α-T levels with FEV₁ and forced vital capacity (FVC) percent predicted. Similarly, models stratified by child α-T tertile evaluated associations of γ-T levels with lung function. We performed similar analyses with maternal second trimester tocopherol isoform levels.

Results

The median maternal second trimester α-T level was 63 μM (interquartile range = 47-82). The median early-childhood level was 25 μM (interquartile range = 20-33 μM). In the lowest tertile of early-childhood γ-T, children with a higher α-T level (per 10 μM) had a higher mid-childhood FEV₁ percent predicted (β = 3.09; 95% CI = 0.58-5.59 and a higher FVC percent predicted (β = 2.77; 95% CI = 0.47-5.06). This protective association of α-T was lost at higher γ-T levels. We did not see any consistent associations of second trimester levels of either α-T or γ-T with mid-childhood FEV₁ or FVC.

Conclusion

When γ-T levels were in the lowest tertile, a higher early-childhood α-T level was associated with better lung function at mid-childhood. Second trimester maternal plasma α-T concentration was 3-fold higher than in the adult nonpregnant female population.

中文翻译：

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生命早期 α- 和 γ- 生育酚与儿童肺功能的关联。

背景

生育酚异构体可以调节儿童肺生长和肺活量测量。

客观的

我们的目的是确定儿童早期或子宫内血浆 α-生育酚 (α-T) 或 γ-生育酚 (γ-T) 异构体水平与儿童肺功能的相关程度。

方法

我们在 Project Viva 队列中纳入了 622 名参与者，他们在儿童中期（6-10 岁）就诊时有肺功能。分别在妊娠中期和 3 岁时通过 HPLC 测量母婴生育酚异构体水平。按儿童 γ-T 水平的三分位数分层的多变量线性回归模型（针对儿童中期体重指数z得分、母亲教育、怀孕期间吸烟和产前直径 <2.5 微米 (PM _2.5 ) 颗粒物暴露进行了调整）是用于评估 α-T 水平与 FEV _1的关联和预测的用力肺活量 (FVC) 百分比。同样，按儿童 α-T 三分位数分层的模型评估了 γ-T 水平与肺功能的关联。我们对孕中期生育酚异构体水平进行了类似的分析。

结果

孕中期 α-T 水平中位数为 63 μM（四分位距 = 47-82）。儿童早期水平的中位数为 25 μM（四分位距 = 20-33 μM）。在儿童早期 γ-T 的最低三分位数中，α-T 水平较高（每 10 μM）的儿童具有较高的儿童中期 FEV ₁ % 预测值（β = 3.09；95% CI = 0.58-5.59 和更高预测的 FVC 百分比（β = 2.77；95% CI = 0.47-5.06）。α-T 的这种保护性关联在 γ-T 水平较高时消失。我们没有看到任何一致的妊娠中期 α-T 或γ-T 与儿童中期 FEV ₁或 FVC。

结论

当 γ-T 水平处于最低三分位数时，较高的儿童早期 α-T 水平与儿童中期较好的肺功能相关。孕中期母体血浆 α-T 浓度是成年非妊娠女性人群的 3 倍。