Abstract

It was found that the use of a new strain-producer Escherichia coli, expressing the heme receptor ChuA, enables obtaining a hemin-containing modular nanotransporter (MNT) for drug delivery into the nuclei of target cells. The hemin-containing MNT becomes stabilized, which leads to an increase in its thermal stability and prevents aggregation of this protein.

中文翻译：

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通过将Hemin嵌入具有血红素受体表达的新菌株中来稳定模块化的纳米转运蛋白。

摘要

已经发现，表达血红素受体ChuA的新的菌株生产者大肠杆菌的使用使得能够获得用于将药物递送到靶细胞核中的含血红素的模块化纳米转运体（MNT）。含血红素的MNT变得稳定，这导致其热稳定性提高并阻止了该蛋白质的聚集。