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Personalized Approach to Determination of Histidine-Rich Glycoprotein and E-Cadherin in Supernatants of Immunocompetent Blood Cells and Breast Biopsy Specimens in Breast Malignant and Non-Malignant Disease.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-04-27 , DOI: 10.1134/s1607672920010019
A I Autenshlyus 1, 2 , A V Bernado 1 , A A Studenikina 1 , A V Proskura 2 , K I Davletova 1 , I P Zhurakovskiy 1, 2 , S A Arkhipov 1, 2 , N A Varaksin 3 , S V Sidorov 4 , V V Lyakhovich 2
Affiliation  

Abstract

The material of patients with invasive carcinoma of no special type (ICNT) and nonmalignant diseases (ND) of the mammary gland was studied. When comparing the concentrations of histidine-rich glycoprotein (HRG) and E-cadherin (CDH1), statistically significant differences between ICNT and ND by HRG in the supernatant of blood cells and its spontaneous production by biopsies and by CDH1 at its induced production, as well as by influence indices of polyclonal activators on the production of CDH1 were found. When comparing the expression of immunohistochemical markers, no statistically significant differences between ICNT and ND were obtained.


中文翻译:

个性化方法,用于测定在乳腺恶性和非恶性疾病中免疫活性血细胞上清液和乳腺活检标本中富含组氨酸的糖蛋白和E-钙黏着蛋白。

摘要

研究了非特殊类型浸润性癌(ICNT)和乳腺非恶性疾病(ND)患者的材料。当比较富含组氨酸的糖蛋白(HRG)和E-钙黏着蛋白(CDH1)的浓度时,HRG在血细胞上清液中的ICNT和ND之间有统计学意义的差异,以及活检和CDH1在诱导产生时的自发产生,如以及通过多克隆激活因子对CDH1产生的影响指数。当比较免疫组化标记物的表达时,在ICNT和ND之间未获得统计学上显着的差异。
更新日期:2020-04-27
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