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De novo assembly transcriptome analysis reveals the preliminary molecular mechanism of pigmentation in juveniles of the hard clam Mercenaria mercenaria.
Genomics ( IF 4.4 ) Pub Date : 2020-04-27 , DOI: 10.1016/j.ygeno.2020.04.020
Zhi Hu 1 , Hao Song 2 , Cong Zhou 1 , Zheng-Lin Yu 2 , Mei-Jie Yang 1 , Tao Zhang 2
Affiliation  

Color plays a vital function in camouflage, sexual selection, immunity, and evolution. Mollusca possess vivid shell colors and pigmentation starts at the juvenile stage. The hard clam Mercenaria mercenaria is a widely cultivated bivalve of high economic value. To explore the molecular mechanism of pigmentation in juvenile clams, here, we performed RNA-Seq analysis on non-pigmented, white, and red M. mercenaria specimens. Clean reads were assembled into 358,285 transcripts and 149,234 unigenes, whose N50 lengths were 2107 bp and 1567 bp, respectively. Differentially expressed genes were identified and analyzed for KEGG enrichment. "Melanoma/Melanogenesis", "ABC transporters", and "Porphyrin and chlorophyll metabolism" pathways appeared to be associated with pigmentation. Pathways related to carotenoid metabolism seemed to also play a vital role in pigmentation in juveniles. Our results provide new insights into the formation of shell color in juvenile hard clams.

中文翻译:

从头组装转录组分析揭示了硬蛤Mercenaria mercenaria幼体色素沉着的初步分子机制。

颜色在伪装、性选择、免疫和进化中起着至关重要的作用。软体动物拥有鲜艳的外壳颜色,色素沉着始于幼年阶段。硬蛤Mercenaria mercenaria 是一种广泛栽培的具有高经济价值的双壳贝类。为了探索幼蛤色素沉着的分子机制,我们在这里对无色素、白色和红色 M. mercenaria 标本进行了 RNA-Seq 分析。Clean read 被组装成 358,285 个转录本和 149,234 个 unigenes,其 N50 长度分别为 2107 bp 和 1567 bp。对差异表达的基因进行鉴定和分析以进行 KEGG 富集。“黑色素瘤/黑色素生成”、“ABC 转运蛋白”和“卟啉和叶绿素代谢”途径似乎与色素沉着有关。与类胡萝卜素代谢相关的途径似乎在幼鱼的色素沉着中也起着至关重要的作用。我们的研究结果为幼年硬蛤壳颜色的形成提供了新的见解。
更新日期:2020-04-27
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