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A Quantitative Framework for Modeling COVID-19 Risk During Adjuvant Therapy Using Published Randomized Trials of Glioblastoma in the Elderly.
Neuro-Oncology ( IF 15.9 ) Pub Date : 2020-04-27 , DOI: 10.1093/neuonc/noaa111
Shervin Tabrizi 1, 2 , Lorenzo Trippa 3 , Daniel Cagney 2 , Shyam Tanguturi 2 , Steffen Ventz 3 , Geoffrey Fell 3 , Patrick Y Wen 4 , Brian M Alexander 2 , Rifaquat Rahman 2
Affiliation  

During the ongoing COVID-19 pandemic, contact with the health care system for cancer treatment can increase risk of infection and associated mortality. Treatment recommendations must consider this risk for elderly and vulnerable cancer patients. We reanalyzed trials in elderly glioblastoma (GBM) patients, incorporating COVID-19 risk, in order to provide a quantitative framework for comparing different radiation (RT) fractionation schedules on patient outcomes.

中文翻译:

使用已发表的老年人胶质母细胞瘤随机试验在辅助治疗过程中模拟COVID-19风险的定量框架。

在持续的COVID-19大流行期间,与医疗保健系统进行癌症治疗接触会增加感染的风险和相关的死亡率。治疗建议必须考虑老年和脆弱癌症患者的这种风险。我们重新分析了老年胶质母细胞瘤(GBM)患者的临床试验,纳入了COVID-19风险,以便为比较不同放射(RT)分馏方案对患者预后的评估提供定量框架。
更新日期:2020-04-27
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