The role of non-neuronal cells in Alzheimer's disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer's disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.

中文翻译：

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阿尔茨海默病和衰老中与疾病相关的星形胶质细胞。

非神经元细胞在阿尔茨海默病进展中的作用尚未完全阐明。使用单核 RNA 测序，我们在阿尔茨海默病小鼠模型中鉴定了一群与疾病相关的星形胶质细胞。这些与疾病相关的星形胶质细胞出现在疾病的早期阶段，并随着疾病的进展大量增加。我们发现类似的星形胶质细胞出现在衰老的野生型小鼠和衰老的人类大脑中，这表明它们与遗传和年龄相关因素有关。