BACKGROUND In Childhood-Onset Systemic Lupus Erythematosus (cSLE), poor medication adherence rates are very high. Interventions targeting this problem in cSLE are limited thus effective interventions are needed. The objective of this study is to examine the feasibility and acceptability an intervention (automated digital reminders + personalized prescribed treatment plan (pPTP)) to improve medication adherence in young adults with cSLE over 3 months. METHOD This is a proof-of-concept randomized controlled study. All participants received SimpleMed+ pillboxes that track adherence. The treatment group received a pPTP, and in month 2, preselected digital reminders for missed doses. Reminders were discontinued after 30 days and adherence data collected. Data analysis was done using t-tests. RESULTS Twenty-one participants were approached and nineteen consented to participate, yielding a recruitment rate of 86%. Participants were on average 20.5 years, mostly black (58%) and female (84%). Of the nineteen consented, eleven were randomized to control (57%) and eight to treatment (42%) groups respectively. All participants in the treatment group rated the pillbox as easy to use, notably; none reported boredom with the pillbox or reminders. Also, 88% of participants in the treatment group rated the pillbox as helpful, however, only 50% reported the pPTP taught them new information about lupus or made them more interested in their lupus management. CONCLUSIONS This is the first use of an electronic pillbox to track adherence to multiple medications in cSLE. The high rating of the pillbox makes it an acceptable method of measuring adherence. Feasibility and acceptability ratings for the intervention were mixed suggesting a there is a subset of cSLE patients for whom this intervention would be beneficial. Future research should focus on a larger trial.

中文翻译：

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对患有儿童期系统性红斑狼疮的年轻成年人进行创新依从性干预的可行性和可接受性。

背景技术在儿童发作性系统性红斑狼疮（cSLE）中，不良的药物依从率非常高。在cSLE中针对此问题的干预措施有限，因此需要有效的干预措施。这项研究的目的是检查干预措施的可行性和可接受性（自动数字提醒+个性化处方治疗计划（pPTP）），以改善3个月以上cSLE的年轻人的药物依从性。方法这是一个概念验证的随机对照研究。所有参与者都收到了追踪依从性的SimpleMed +药盒。治疗组接受了pPTP，并在第2个月预先选择了数字提醒以提醒您错过剂量。30天后停止提醒，并收集依从性数据。数据分析使用t检验进行。结果与21名参与者进行了接触，其中19名同意了参与者，招聘率为86％。参与者的平均年龄为20.5岁，其中大多数是黑人（58％）和女性（84％）。在同意的19个患者中，有11个分别被随机分为对照组（57％）和8个为治疗组（42％）。治疗组的所有参与者均将药盒评为易于使用，尤其是；没有人报告对药盒或催眠剂感到无聊。同样，治疗组中88％的参与者认为药盒是有帮助的，但是，只有50％的人报告说pPTP教会了他们有关狼疮的新信息，或者使他们对狼疮的治疗更加感兴趣。结论这是电子药盒首次用于追踪cSLE中多种药物的依从性。药盒的高评级使其成为衡量附着力的可接受方法。干预措施的可行性和可接受性等级参差不齐，这表明有一部分cSLE患者对此干预措施将是有益的。未来的研究应将重点放在更大的试验上。