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The role of Neurotensin and its receptors in non-gastrointestinal cancers: a review.
Cell Communication and Signaling ( IF 8.4 ) Pub Date : 2020-04-26 , DOI: 10.1186/s12964-020-00569-y
Stella Nikolaou 1, 2, 3 , Shengyang Qiu 1, 3 , Francesca Fiorentino 3 , Constantinos Simillis 1 , Shahnawaz Rasheed 1, 2, 3 , Paris Tekkis 1, 2, 3 , Christos Kontovounisios 1, 2, 3
Affiliation  

BACKGROUND Neurotensin, originally isolated in 1973 has both endocrine and neuromodulator activity and acts through its three main receptors. Their role in promoting tumour cell proliferation, migration, DNA synthesis has been studied in a wide range of cancers. Expression of Neurotensin and its receptors has also been correlated to prognosis and prediction to treatment. MAIN BODY The effects of NT are mediated through mitogen-activated protein kinases, epidermal growth factor receptors and phosphatidylinositol-3 kinases amongst others. This review is a comprehensive summary of the molecular pathways by which Neurotensin and its receptors act in cancer cells. CONCLUSION Identifying the role of Neurotensin in the underlying molecular mechanisms in various cancers can give way to developing new agnostic drugs and personalizing treatment according to the genomic structure of various cancers. Video abstract.

中文翻译:

神经降压素及其受体在非胃肠道癌症中的作用:综述。

背景神经降压素最初于 1973 年分离,具有内分泌和神经调节活性,并通过其三个主要受体起作用。它们在促进肿瘤细胞增殖、迁移、DNA 合成方面的作用已在广泛的癌症中得到研究。神经降压素及其受体的表达也与预后和治疗预测相关。主体 NT 的作用是通过丝裂原活化蛋白激酶、表皮生长因子受体和磷脂酰肌醇 3 激酶等介导的。这篇综述全面总结了神经降压素及其受体在癌细胞中起作用的分子途径。结论 确定神经降压素在各种癌症的潜在分子机制中的作用可以让位于根据各种癌症的基因组结构开发新的不可知药物和个性化治疗。视频摘要。
更新日期:2020-04-26
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