In this research, a novel procedure for the synthesis of pyrazole derivatives in excellent yields was studied using catalyst‐free multicomponent reaction of isoquinoline, activated acetylenic compounds, alkyl bromides, triphenylphosphine and hydrazine in water under ultrasonic irradiation at room temperature. The advantages of this procedure than to reported methods are short time of reaction, high yields of product, easy separation of product, clean mixture of reaction and green media for performing reaction. In addition, because of having pyrazole and isoquinoline core in the synthesized compounds, in this research, antioxidant activity of some synthesized compounds was investigated.

中文翻译：

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无催化剂的绿色合成和新型吡唑衍生物的抗氧化活性研究

在这项研究中，研究了使用异喹啉，活化的炔属化合物，烷基溴化物，三苯膦和肼在室温下于室温下进行的无催化剂多组分反应，以优异的产率合成了吡唑衍生物的新方法。该方法比报道的方法的优点是反应时间短，产物的产率高，产物易于分离，反应的清洁混合物和用于进行反应的绿色介质。另外，由于合成物中具有吡唑和异喹啉核心，本研究对一些合成化合物的抗氧化活性进行了研究。