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Pregestational diabetes in pregnancy: Complications, management, surveillance, and mechanisms of disease-Ā review.
Prenatal Diagnosis ( IF 3 ) Pub Date : 2020-04-25 , DOI: 10.1002/pd.5718
Alexis Shub 1, 2 , Martha Lappas 1
Affiliation  

Diabetes is an increasingly common diagnosis among pregnant women. Pregestational diabetes is associated with an increase in many adverse pregnancy outcomes, which impact both on the woman and her fetus. The models of pregnancy care for women with diabetes are based largely on observational data or consensus opinion. Strategies for aneuploidy screening and monitoring for fetal well‐being should be modified in women with diabetes. There is an increasing understanding of the mechanisms by which congenital anomalies and disorders of fetal growth occur, involving epigenetic modifications, changes in gene expression in critical developmental pathways, and oxidative stress. This knowledge may lead to pathways for improved care for these high‐risk pregnancies.

中文翻译:

妊娠期妊娠前糖尿病:并发症、管理、监测和疾病机制--回顾。

糖尿病是孕妇中越来越常见的诊断。孕前糖尿病与许多不良妊娠结局的增加有关,这对女性和胎儿都有影响。糖尿病妇女的妊娠护理模型主要基于观察数据或共识意见。应修改糖尿病女性的非整倍体筛查和胎儿健康监测策略。人们越来越了解先天性异常和胎儿生长障碍发生的机制,包括表观遗传修饰、关键发育途径中基因表达的变化和氧化应激。这些知识可能会导致改善对这些高危妊娠的护理的途径。
更新日期:2020-04-25
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