Given their polyvalent functions, an inherent challenge that mitochondria face is the exposure to mitochondrial import stresses, culminating in their dysfunction. Recently, mitochondrial import of several mitochondrial substrates was shown to be regulated via a 'tug of war' between USP30 and MARCH5, two ubiquitin-related enzymes located at the TOM complex.

中文翻译：

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通过泛素微调TOM线粒体导入。

考虑到它们的多价功能，线粒体面临的固有挑战是暴露于线粒体输入压力，最终导致其功能障碍。最近，通过USP30和MARCH5（位于TOM复合体中的两种泛素相关酶）之间的“拔河”，显示了几种线粒体底物的线粒体进口受到调控。