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Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues.
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2020-04-25 , DOI: 10.1016/j.tibs.2020.04.003
Alisdair R Fernie 1 , Youjun Zhang 1 , Arun Sampathkumar 2
Affiliation  

Energy-demanding processes, such as cell growth, migration, and differentiation, are tension modulated, begging the question whether metabolism and mechanical tension are tightly linked. A recent report by Park et al. shows that stiffness in the extracellular matrix (ECM) promotes reorganization of actin, resulting in enhanced glycolysis.



中文翻译:

细胞骨架结构调节糖酵解将细胞代谢耦合到机械提示。

诸如细胞生长,迁移和分化等能量需求过程受到张力调节,这引发了新陈代谢和机械张力是否紧密联系的问题。Park等人的最新报告结果表明,细胞外基质(ECM)的硬度促进肌动蛋白的重组,导致糖酵解增强。

更新日期:2020-04-25
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