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106 “Random Twitching” - A Case Presentation
CNS Spectrums ( IF 3.3 ) Pub Date : 2020-04-24 , DOI: 10.1017/s1092852920000243
Andrew Ruege

:Purpose of the study:To present a case about a 12 year old with a movement disorder to educate the community about an uncommon side effect of a commonly utilized class of psychiatric medications. Simple statement of methods: Patient was seen in the context of a consultation-liaison psychiatry capacity during the first author’s general psychiatry residency. Information was obtained from an electronic medical record and interviews with other physicians that treated the patient. Research about the patient’s supposed diagnosis was conducted using a PubMed + OneSearch searches and articles were obtained under the guidance of a certified hospital librarian.Results/Discussion:Withdrawal Emergent Dyskinesia is an uncommon, but debilitating condition that can occur after a rapid discontinuation/dosage change of a neuroleptic. This condition has been documented sparsely in the literature; more literature exists regarding its presence in children than in adults. The condition lasts for 2-3 months and resolves spontaneously in ~90% of cases. The literature that is available suggests (1) avoiding neuroleptic use in children if possible, (2) tapering off antipsychotics slowly, (3) using benzodiazepines and/or beta-blockers to treat symptoms of this condition, and (4) restarting the neuroleptic if symptoms do not improve.Conclusion:Withdrawal Emergent Dyskinesia is an uncommon, poorly studied, debilitating condition that can occur after a rapid discontinuation/dosage change of a neuroleptic. Future research efforts could be focused on (a) the prevalence of neuroleptic withdrawal symptoms in both adults and children, (b) the complete neurochemical and neurobiological pathogenesis of WED, and (c) the differences in terms of diagnosis and treatment between dyskinesias associated with both neuroleptic use and/or withdrawal. In addition, the existence of such a condition is yet another reason to reconsider off-label use of neuroleptics to treat behavioral symptoms in the absence of clear psychiatric indications for their use.

中文翻译:

106“随机抽搐”——案例展示

:研究目的:介绍一个关于 12 岁患有运动障碍的案例,以向社区宣传一种常用的精神科药物的不常见副作用。方法的简单说明:在第一作者的普通精神病学住院医师期间,患者在咨询-联络精神病学能力的背景下进行了观察。信息是从电子病历和与治疗患者的其他医生的访谈中获得的。使用 PubMed + OneSearch 搜索对患者的假定诊断进行了研究,并在经过认证的医院图书馆员的指导下获得了文章。结果/讨论:戒断紧急运动障碍是一种不常见但可能在快速停药/给药后出现的衰弱状况更换神经阻滞剂。这种情况在文献中很少记载。关于其存在于儿童中的文献比存在于成人中的文献更多。病情持续 2-3 个月,约 90% 的病例会自行消退。现有文献表明:(1) 尽可能避免在儿童中使用抗精神病药,(2) 缓慢减少抗精神病药的用量,(3) 使用苯二氮卓类药物和/或 β 受体阻滞剂来治疗这种疾病的症状,以及 (4) 重新使用抗精神病药如果症状没有改善。结论:戒断性突发性运动障碍是一种罕见的、研究较少的、使人衰弱的疾病,可能在快速停药/改变抗精神病药剂量后发生。未来的研究工作可以集中在 (a) 成人和儿童中神经安定药戒断症状的普遍性,(b) WED 的完整神经化学和神经生物学发病机制,以及 (c) 与精神抑制药使用和/或戒断相关的运动障碍在诊断和治疗方面的差异。此外,这种情况的存在是重新考虑在没有明确的精神病学适应症的情况下使用精神安定药治疗行为症状的另一个原因。
更新日期:2020-04-24
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