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Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer.
Microbiology and Molecular Biology Reviews ( IF 12.9 ) Pub Date : 2020-03-04 , DOI: 10.1128/mmbr.00064-19
Matteo Bellone 1 , Arianna Brevi 2, 3 , Samuel Huber 4
Affiliation  

SUMMARYTechnologies allowing genetic sequencing of the human microbiome are opening new realms to discovery. The host microbiota substantially impacts immune responses both in immune-mediated inflammatory diseases (IMIDs) and in tumors affecting tissues beyond skin and mucosae. However, a mechanistic link between host microbiota and cancer or IMIDs has not been well established. Here, we propose T helper 17 (TH17) lymphocytes as the connecting factor between host microbiota and rheumatoid or psoriatic arthritides, multiple sclerosis, breast or ovarian cancer, and multiple myeloma. We theorize that similar mechanisms favor the expansion of gut-borne TH17 cells and their deployment at the site of inflammation in extraborder IMIDs and tumors, where TH17 cells are driving forces. Thus, from a pathogenic standpoint, tumors may share mechanistic routes with IMIDs. A review of similarities and divergences in microbiota-TH17 cell interactions in IMIDs and cancer sheds light on previously ignored pathways in either one of the two groups of pathologies and identifies novel therapeutic avenues.

中文翻译:

微生物群推动的T辅助17细胞在炎症性疾病和癌症中的作用。

概要允许对人类微生物组进行基因测序的技术为发现开辟了新领域。宿主菌群在免疫介导的炎性疾病(IMID)和影响皮肤和粘膜以外组织的肿瘤中均会显着影响免疫反应。但是,宿主微生物群与癌症或IMID之间的机制联系尚未建立。在这里,我们建议T辅助17(TH17)淋巴细胞作为宿主微生物群与类风湿或银屑病关节炎,多发性硬化症,乳腺癌或卵巢癌以及多发性骨髓瘤之间的连接因子。我们推论,类似的机制有利于肠道携带的TH17细胞的扩增以及它们在TH17细胞驱动力的边界IMID和肿瘤中炎症部位的部署。因此,从致病的角度来看,肿瘤可能与IMID共享机械途径。IMIDs和癌症中微生物群-TH17细胞相互作用的相似性和分歧的综述揭示了两组病理学中任何一种之前被忽略的途径,并确定了新的治疗途径。
更新日期:2020-03-04
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