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Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery
Planta Medica ( IF 2.7 ) Pub Date : 2020-04-25 , DOI: 10.1055/a-1140-8388
Pragya Paramita Pal 1 , Ameer Basha Shaik 2 , A Sajeli Begum 1
Affiliation  

A wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. "Bio-actives of endophytic origin" is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification of secondary metabolites. The compounds were identified to possess activity against a total of 16 anti-inflammatory targets. The most common targets involved were NO, TNF-α, and inhibition of total ROS. Further, the article gives a detailed insight into the compounds, their endophytic source, and anti-inflammatory target as well as potency. The contents of the article cover all the scientific reports published until Feb. 2019. Thus 118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities. Amongst these, herbarin, periconianone A, and periconianone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.

中文翻译:

内生真菌用于抗炎药物发现的潜在线索

从天然来源中分离出的化合物已表现出广泛的治疗效果。“内生源生物活性物质”是最近探索的领域,在过去的 20 年中得到了认可。对内生菌次级代谢产物的文献检索显示了几种具有药理活性的化合物,尤其是抗炎化合物,本文对其进行了综述。文章的结构基于次生代谢物的化学分类。经鉴定,这些化合物对总共 16 个抗炎靶标具有活性。最常见的目标是 NO、TNF-α 和总 ROS 的抑制。此外,该文章详细介绍了这些化合物、它们的内生来源、抗炎靶点以及效力。文章内容涵盖了截至 2019 年 2 月发表的所有科学报告。因此,据报道,从内生来源获得了 118 种化合物和 6 种提取物,显示出抗炎活性。其中,就其对 NO 抑制的 IC50 值而言,herbarin、periconianone A 和 periconianone B 被鉴定为最有效的化合物。
更新日期:2020-04-25
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