Globus is a non‐painful sensation of a tightness or a lump/foreign body in the throat that is not associated with dysphagia and may actually improve during meals. While several otorhinolaryngologic, thyroid, and esophageal disorders have been linked to globus, cause‐and‐effect relationships are difficult to establish. Consequently, though part of the evaluation, objective otorhinolaryngologic and esophageal testing is often negative. The presence of alarm symptoms, particularly pain, weight loss, dysphagia, or odynophagia is indications for objective testing. A diagnosis of idiopathic globus requires exclusion of pharyngeal, laryngeal, and esophageal disorders with laryngoscopy, endoscopy, high‐resolution manometry, barium radiography, and/or ambulatory reflux monitoring. A trial of acid‐suppressive therapy may be reasonable in the absence of alarm symptoms, especially if concurrent reflux symptoms are identified. Ablation of heterotopic gastric mucosa in the proximal esophagus has been reported to improve globus symptoms. Beyond these specific approaches, further management of idiopathic globus consists of reassurance, neuromodulators, and complementary approaches. Globus has a benign course with no long‐term consequences, and the overall prognosis is good as the magnitude of symptoms may decline over time.

中文翻译：

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ESNM / ANMS审查。globus感觉的诊断和管理：临床挑战。

Globus是喉咙发紧或肿块/异物的无痛感，与吞咽困难无关，进餐时可能会有所改善。虽然几种耳鼻喉科疾病，甲状腺疾病和食管疾病与全球性疾病有关，但因果关系很难建立。因此，尽管是评估的一部分，但客观的耳鼻喉科和食道检查通常是阴性的。出现警报症状，特别是疼痛，体重减轻，吞咽困难或吞咽困难，是进行客观检查的指征。诊断特发性小球需要通过喉镜，内窥镜检查，高分辨率测压，钡剂造影和/或非卧床反流监测排除咽，喉和食道疾病。在没有警报症状的情况下，尝试酸抑制疗法可能是合理的，特别是如果确定同时出现反流症状。据报道，近端食管的异位胃粘膜消融可改善globus症状。除了这些特定的方法外，特发性小球的进一步管理还包括放心，神经调节剂和补充方法。Globus的病程良好，没有长期后果，并且总体预后良好，因为症状的严重程度可能会随时间而下降。和补充方法。Globus的病程良好，没有长期后果，并且总体预后良好，因为症状的严重程度可能会随时间而下降。和补充方法。Globus的病程良好，没有长期后果，并且总体预后良好，因为症状的严重程度可能会随时间而下降。