The ongoing outbreak of the novel coronavirus (SARS-CoV-2) infection is creating serious challenges for health laboratories that seek to identify viral infections as early as possible, optimally at the earliest appearance of symptom. Indeed, there is urgent need to develop and deploy robust diagnostic methodologies not only to use in health laboratory environments but also directly in places where humans circulate and spread the virus such as airports, trains, boats, and any public aggregation places. The success of a reliable and sensitive asymptomatic diagnosis relies on the identification and measurement of informative biomarkers from human host and virus in a rapid, sensitive, and inexpensive manner. The objective of this article is to describe an innovative multidisciplinary approach to develop an efficient, inexpensive, and easy-to-use portable instrument (bCUBE® by Hyris Ltd) that can be employed as a surveillance system for the emergency caused by SARS-CoV-2. A solution for Coronavirus testing, compliant with CDC guidelines, is scheduled to be released in the next weeks. In addition, we will describe a workflow and path of an integrated multi-omic approach that will lead to host and pathogen biomarker discovery in order to train the instrument to provide reliable results based on a specific biomarker's fingerprint of SARS-CoV-2 infection.

中文翻译：

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便携式仪器在任何环境中快速，可靠地检测SARS-CoV-2感染的应用。

新型冠状病毒（SARS-CoV-2）感染的持续爆发给健康实验室带来了严峻的挑战，这些实验室希望尽早，最好在症状最早出现时就识别出病毒感染。确实，迫切需要开发和部署强大的诊断方法，不仅在健康实验室环境中使用，而且直接在人类传播和传播病毒的地方（例如机场，火车，轮船和任何公共聚集场所）使用。可靠和敏感的无症状诊断的成功取决于以快速，敏感和廉价的方式从人宿主和病毒中鉴定和测量信息性生物标志物。本文的目的是描述一种创新的多学科方法，以开发一种高效，廉价的，以及易于使用的便携式仪器（Hyris Ltd.的bCUBE®），可用作SARS-CoV-2引起的紧急情况的监视系统。符合CDC准则的冠状病毒测试解决方案计划于下周发布。此外，我们将描述集成多体组学方法的工作流程和路径，该方法将导致宿主和病原体生物标记物的发现，以便训练该仪器根据SARS-CoV-2感染的特定生物标记物的指纹提供可靠的结果。