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Diterpenoids and Flavonoids from the Twigs of Cephalotaxus fortunei var. alpina
Chemistry & Biodiversity ( IF 2.9 ) Pub Date : 2020-06-01 , DOI: 10.1002/cbdv.202000210
Qing-Pu Huang 1, 2 , Kai Guo 1, 2 , Yan Liu 1 , Yan-Chun Liu 1 , Wen-Yuan Li 1, 2 , Hao Geng 1, 2 , Ying Wang 1, 2 , Sheng-Hong Li 1
Affiliation  

Three new diterpenoids (a cephalotane, an abietane and a 9(10→20)‐abeo‐abietane) and one new flavonoid, together with 11 known compounds, were isolated from the twigs of Cephalotaxus fortunei var. alpina. The new compounds were identified by comprehensive spectroscopic (including 1D and 2D‐NMR and HR‐ESI‐MS) analysis. Anti‐inflammatory, immunosuppressive and cytotoxic activities of three new compounds were evaluated. 3β,20‐epoxyabieta‐8,11,13‐triene‐3α,12‐diol showed weak cytotoxicity against tumor cell lines NCI−H1975, HepG2, MCF‐7, while fortalpinoid R and 3‐acetonyl‐3,5,7,4′‐tetrahydroxy‐2‐methoxyflavanone were not active at 80 μM. None of these compounds showed anti‐inflammatory and immunosuppressive activities.

中文翻译:

来自 Cephalotaxus Fortunei var. 枝条的二萜类化合物和黄酮类化合物。高山

从 Cephalotaxus Fortunei var. 的枝条中分离出三种新的二萜类化合物(一种头孢烷、一种松香烷和一种 9(10→20)-abeo-abietane)和一种新的黄酮类化合物以及 11 种已知化合物。阿尔宾娜。通过综合光谱(包括 1D 和 2D-​​NMR 和 HR-ESI-MS)分析鉴定了新化合物。评估了三种新化合物的抗炎、免疫抑制和细胞毒性活性。3β,20-epoxyabieta-8,11,13-triene-3α,12-diol 对肿瘤细胞系 NCI-H1975、HepG2、MCF-7 显示出弱的细胞毒性,而 fortalpinoid R 和 3-acetonyl-3,5,7, 4'-四羟基-2-甲氧基黄烷酮在 80 μM 时没有活性。这些化合物均未显示抗炎和免疫抑制活性。
更新日期:2020-06-01
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