This paper describes the stimuli-responsive hydrogels constructed from bola-type amphiphiles composed of two dipeptides containing phenylalanine attached to the ends of a hydrophobic tetrathiophene. The hydrogel formation ability of the amphiphiles was affected by the N -terminal amino acid residue, which is an amphiphile-possessing phenylalanine-lysine sequence that formed a hydrogel under limited pH conditions. Gel formation occurred because of the phase transition of the gelator assembly from a granular aggregate to a fibrous architecture, in a process controlled by pH. This stimuli-responsive sol–gel transition was also accomplished by the addition of an anionic polymer, and sulfated glycosaminoglycans were successfully discriminated using the hydrogel system. A bola-type π -conjugated amphiphile containing Phe-Lys dipeptide showed a pH- and guest-induced phase transition from the granular aggregate to the fibrous architecture and formed a supramolecular hydrogel. Using this stimuli-responsiveness, the hydrogel system was successfully applied to the selective discrimination of glycosaminoglycans composed of a sulfated sugar unit.

中文翻译：

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客体响应超分子水凝胶表达硫酸化糖胺聚糖的选择性溶胶-凝胶转变

本文描述了由 bola 型两亲分子构建的刺激响应水凝胶，该分子由两个二肽组成，苯丙氨酸连接到疏水四噻吩的末端。两亲物的水凝胶形成能力受 N 端氨基酸残基的影响，这是一种具有苯丙氨酸 - 赖氨酸序列的两亲物，在有限的 pH 条件下形成水凝胶。凝胶形成的原因是凝胶剂组件在由 pH 控制的过程中从粒状聚集体到纤维结构的相变。这种刺激响应性溶胶-凝胶转变也是通过添加阴离子聚合物来实现的，并且使用水凝胶系统成功区分了硫酸化糖胺聚糖。含有 Phe-Lys 二肽的 bola 型 π 共轭两亲物显示出从颗粒聚集体到纤维结构的 pH 值和客体诱导的相变，并形成了超分子水凝胶。使用这种刺激响应性，水凝胶系统成功地应用于选择性区分由硫酸化糖单元组成的糖胺聚糖。