Background

Surface enhanced Raman scattering (SERS) based on highly sensitive, flexible, solid-state sensors can provide molecular vibrational fingerprints of targeted substances in point-of-care (POC) analysis. Cellulose paper offers many advantages for the build-up of silver and gold nanostructures on a three-dimensional scaffold. Such composites can be made to contain SERS hot spots required for sensitive SERS detection in an active solid-state sensor.

Scope and approach

In this review, we discuss the key technical issues involved in the fabrication of SERS sensors combining a metallic SERS substrate and a cellulose paper support. We then survey recent literature for methods designed to address these issues with applications to support food safety where POC analysis serves as a valuable tool.

Key findings and conclusions

Sensitivity of detection is a primal challenge in the development of a paper-based SERS substrate. The fibril structures of paper materials, a suitable modification for improved bonding at the paper-metal interface, and the surface conditions of metal nanostructures all contribute to sensitive SERS performance on paper. Continuing expansion of spectrum collection in a database format, diverse methods for the statistical analyses of Raman spectra, and advanced integration of portable Raman instruments with the mobile tele-networks are critical in the further development of flexible SERS sensor in POC testing of food-borne substances.

中文翻译：

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纸质柔性表面增强拉曼散射平台及其在食品安全中的应用

背景

基于高度灵敏，灵活的固态传感器的表面增强拉曼散射（SERS）可以在即时护理（POC）分析中提供目标物质的分子振动指纹。纤维素纸为在三维支架上构建银和金纳米结构提供了许多优势。可以使此类复合材料包含主动固态传感器中灵敏SERS检测所需的SERS热点。

范围和方法

在这篇综述中，我们讨论了结合金属SERS基底和纤维素纸支架的SERS传感器制造中涉及的关键技术问题。然后，我们将对最近的文献进行调查，寻找旨在解决这些问题的方法，并在POC分析可作为有价值的工具的应用中支持食品安全。

主要发现和结论

在纸基SERS基材的开发中，检测的灵敏度是首要挑战。纸材料的原纤维结构，用于改善纸-金属界面处的粘合力的适当修饰以及金属纳米结构的表面条件，都对纸的敏感SERS性能有贡献。在数据库格式中频谱收集的持续扩展，拉曼光谱统计分析的各种方法以及便携式拉曼仪器与移动电信网络的高级集成对于在食品级POC测试中灵活SERS传感器的进一步发展至关重要物质。