Camptothecin (CPT) and its analogues show potent antitumour activity. However, poor water solubility and severe side effects have restricted their applications in clinical practice. In this paper, a novel self‐assembly based on camptothecin and carbamoylmannose conjugates (CPT‐Man) was constructed. The self‐assembly increased the water solubility of camptothecin to 0.64 mg/ml and antitumour activity. Moreover, CPT‐Man could induce obvious cancer cell apoptosis. This work provides a new approach for exploring carbohydrate‐modified antitumour properties by self‐assembled CPT drugs.

中文翻译：

---

基于喜树碱和氨基甲酰甘露糖缀合物自组装的抗肿瘤特性。

喜树碱 (CPT) 及其类似物显示出有效的抗肿瘤活性。然而，水溶性差和严重的副作用限制了它们在临床实践中的应用。在本文中，构建了一种基于喜树碱和氨基甲酰甘露糖缀合物 ( CPT-Man )的新型自组装体。自组装将喜树碱的水溶性增加到 0.64 mg/ml 和抗肿瘤活性。此外，CPT-Man可以诱导明显的癌细胞凋亡。这项工作为通过自组装 CPT 药物探索碳水化合物修饰的抗肿瘤特性提供了一种新方法。