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SERS Barcode Libraries: A Microfluidic Approach.
Advanced Science ( IF 15.1 ) Pub Date : 2020-04-22 , DOI: 10.1002/advs.201903172
Semih Sevim 1 , Carlos Franco 1 , Xiang-Zhong Chen 2 , Alessandro Sorrenti 1 , David Rodríguez-San-Miguel 1 , Salvador Pané 2 , Andrew J deMello 1 , Josep Puigmartí-Luis 1
Affiliation  

Microfluidic technologies have emerged as advanced tools for surface‐enhanced Raman spectroscopy (SERS). They have proved to be particularly appealing for in situ and real‐time detection of analytes at extremely low concentrations and down to the 10 × 10−15 m level. However, the ability to prepare reconfigurable and reusable devices endowing multiple detection capabilities is an unresolved challenge. Herein, a microfluidic‐based method that allows an extraordinary spatial control over the localization of multiple active SERS substrates in a single microfluidic channel is presented. It is shown that this technology provides for exquisite control over analyte transport to specific detection points, while avoiding cross‐contamination; a feature that enables the simultaneous detection of multiple analytes within the same microfluidic channel. Additionally, it is demonstrated that the SERS substrates can be rationally designed in a straightforward manner and that they allow for the detection of single molecules (at concentrations as low as 10−14 m ). Finally, it is shown that rapid etching and reconstruction of SERS substrates provides for reconfigurable and reusable operation.

中文翻译:

SERS 条形码库:微流体方法。

微流控技术已成为表面增强拉曼光谱(SERS)的先进工具。事实证明,它们对于极低浓度和低至 10 × 10 -15  m水平的分析物的原位实时检测特别有吸引力。然而,制备具有多种检测功能的可重构和可重复使用的设备的能力是一个尚未解决的挑战。本文提出了一种基于微流体的方法,可以对单个微流体通道中多个活性 SERS 基底的定位进行非凡的空间控制。结果表明,该技术可以精确控制分析物传输到特定检测点,同时避免交叉污染;该功能能够同时检测同一微流体通道内的多种分析物。此外,还证明了SERS基底可以以简单的方式合理设计,并且它们允许检测单分子(浓度低至10 -14  m)。最后,研究表明,SERS 基底的快速蚀刻和重建提供了可重新配置和可重复使用的操作。
更新日期:2020-06-24
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