当前位置: X-MOL 学术Crit. Rev. Biotechnol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Insights into the N6-methyladenosine mechanism and its functionality: progress and questions.
Critical Reviews in Biotechnology ( IF 9 ) Pub Date : 2020-04-22 , DOI: 10.1080/07388551.2020.1751059
Margaret Scarrow 1 , Ning Chen 1 , Genlou Sun 1
Affiliation  

N6-methyladenosine (m6A) RNA methylation has become a progressively popular area of molecular research since the discovery of its potentially essential regulatory role amongst eukaryotes. m6A marks are observed in the 5'UTR, 3'UTR and coding regions of eukaryotes and its mediation has been associated with various human diseases, RNA stability and translational efficiency. To understand the implications of m6A methylation in molecular governance, its functionality and mechanism must be initially understood. m6A regulation through its readers, writers and erasers as well as an insight into the potential "cross-talk" occurring between m6A and previously well documented regulatory molecular mechanisms have been characterized. The majority of research to date has been limited to few species and has yet to explore the species- and tissue specific nature or mechanistic plasticity of m6A regulation. There is still a tremendous gap in our knowledge surrounding the mechanism and functionality of m6A RNA methylation. Here we review the formation, removal, and decoding of m6A amongst animals, yeast, and plants while noting potential "cross-talk" between various mechanisms and highlighting potential areas of future research.

中文翻译:

深入了解 N6-甲基腺苷机制及其功能:进展和问题。

N6-甲基腺苷 (m6A) RNA 甲基化自从发现其在真核生物中的潜在重要调节作用以来,已逐渐成为分子研究的热门领域。在真核生物的 5'UTR、3'UTR 和编码区中观察到 m6A 标记,其介导与各种人类疾病、RNA 稳定性和翻译效率有关。要了解 m6A 甲基化在分子治理中的影响,必须首先了解其功能和机制。通过读取器、写入器和擦除器对 m6A 进行调节,以及对 m6A 与先前有据可查的调节分子机制之间发生的潜在“串扰”的深入了解。迄今为止,大多数研究仅限于少数物种,尚未探索 m6A 调节的物种和组织特异性性质或机械可塑性。关于 m6A RNA 甲基化的机制和功能,我们的知识仍然存在巨大差距。在这里,我们回顾了动物、酵母和植物中 m6A 的形成、去除和解码,同时注意到各种机制之间的潜在“串扰”,并突出了未来研究的潜在领域。
更新日期:2020-04-22
down
wechat
bug