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Neuromelanin accumulation in Substantia nigra in vascular parkinsonism.
Journal of Neural Transmission ( IF 3.3 ) Pub Date : 2020-04-23 , DOI: 10.1007/s00702-020-02191-1
Carlos Eduardo Mantese 1 , Tulio Becker Hainzenreder 2
Affiliation  

Vascular parkinsonism (VaP) is a term used to describe a parkinsonism of vascular cause. However, only ischemic or hemorrhagic lesions in the substantia nigra or nigrostriatal pathway, leading to a reduction of dopaminergic stimulus are pure VaP. Here, we report a case of true VaP due to nigrostriatal pathway stroke with accumulation of neuromelanin in Substantia nigra. This is the first description of neuromelanin accumulation from nigrostriatal damage. Also, it can help to understand the physiopathological changes in VaP.

中文翻译:

血管性帕金森病黑质中的神经黑色素积累。

血管性帕金森综合征 (VaP) 是用于描述血管性帕金森综合征的术语。然而,只有黑质或黑质纹状体通路中的缺血性或出血性病变导致多巴胺能刺激减少,才是纯 VaP。在这里,我们报告了一个真正的 VaP 病例,这是由于黑质纹状体通路中风和黑质中神经黑色素的积累。这是对黑质纹状体损伤引起的神经黑色素积累的首次描述。此外,它可以帮助了解 VaP 的病理生理变化。
更新日期:2020-04-23
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