Hericium erinaceus is a very popular edible and medicinal mushroom used for the treatment of enervation and gastrointestinal diseases in Eastern Asia. Chemical investigation on the fruiting body of Hericium erinaceus led to the isolation of 4 new (1: - 4: ) and 10 known meroterpenoids (5: - 14: ). The structures of new compounds were determined via analysis of NMR and MS data in combination with chemical derivatization. The inhibitory activities of 1: - 14: against α-glucosidase were evaluated using p-nitrophenyl-α-D-glucopyranoside, sucrose, or maltose as substrate. Compounds 6, 9, 11: - 13: were demonstrated to show the α-glucosidase inhibitory activities. This work confirms the potential of H. erinaceus in the treatment of diabetes.

中文翻译：

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猴头菇类萜的鉴定及α-葡萄糖苷酶抑制活性

猴头菇是一种非常受欢迎的食用和药用蘑菇，用于治疗东亚地区的神经衰弱和胃肠疾病。猴头菇子实体的化学研究导致分离出 4 种新的 (1: - 4: ) 和 10 种已知的类萜 (5: - 14: )。新化合物的结构是通过 NMR 和 MS 数据分析结合化学衍生化确定的。使用对硝基苯基-α-D-吡喃葡萄糖苷、蔗糖或麦芽糖作为底物评价1:-14:对α-葡萄糖苷酶的抑制活性。化合物6, 9, 11: - 13: 被证明显示出α-葡萄糖苷酶抑制活性。这项工作证实了猴头菌在治疗糖尿病方面的潜力。