Abstract As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept through 213 countries and infected more than 1,870,000 individuals, posing an unprecedented threat to international health and the economy. There is currently no specific treatment available for patients with COVID-19 infection. The lessons learned from past management of respiratory viral infections have provided insights into treating COVID-19. Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. A number of these therapies have provided substantially curative benefits in treating patients with COVID-19 infection. Furthermore, intensive research and clinical trials are underway to assess the efficacy of existing drugs and identify potential therapeutic targets to develop new drugs for treating COVID-19. Herein, we summarize the current potential therapeutic approaches for diseases related to COVID-19 infection and introduce their mechanisms of action, safety, and effectiveness.

中文翻译：

---

COVID-19危机潜在治疗候选药物的现状

摘要 截至2020年4月15日，2019冠状病毒病（COVID-2019）大流行已席卷213个国家，感染人数超过187万人，对国际健康和经济构成前所未有的威胁。目前尚无针对 COVID-19 感染患者的具体治疗方法。从过去的呼吸道病毒感染管理中吸取的经验教训为治疗 COVID-19 提供了见解。许多潜在的治疗方法，包括支持性干预、免疫调节剂、抗病毒治疗和恢复期血浆输注，已初步应用于临床。其中许多疗法为治疗 COVID-19 感染患者提供了显着的疗效。此外，正在进行深入研究和临床试验，以评估现有药物的疗效并确定潜在的治疗靶点，以开发治疗 COVID-19 的新药。在此，我们总结了当前与 COVID-19 感染相关疾病的潜在治疗方法，并介绍了其作用机制、安全性和有效性。