Zwitterionic monomer methyacryloxyethyl sulfobetaine (MAES) copolymerized with hydroxyethyl methacrylate (HEMA) forming random copolymer with some block characteristics in a controlled manner. The polyzwitterionic copolymer P(MAESx-ran-HEMAy) (PMxHy, where x and y were the degrees of polymerization of MAES and HEMA, respectively), which bearing hydroxyl groups that served as both reducing and capping reagent for in situ AgNPs synthesis without exogenous additions. The in situ formed uniform AgNPs composites adopted a typical “core-shell” structure where AgNPs served as cores, and PMH were shells. The stability of the AgNPs composites was promoted by chelation of AgNPs core and the generated aldehyde on PMH during silver ions (Ag⁺ ions) reduction. Size of the AgNPs composites directly correlated with [MAES] to [HEMA] ratio in PMH and the highest yield of AgNPs composites was achieved when PM20H27 to AgNO₃ weight ratio equaled 30%. The AgNPs composites originating from PM50H26 showed the most potent bactericidal activity through the membrane perturbation mechanism. Besides, the AgNPs composites confirmed safe for mammalian cells by hemolysis and cytotoxicity tests.

两性离子单体甲基丙烯酰氧基乙基磺基甜菜碱（MAES）与甲基丙烯酸羟乙酯（HEMA）共聚，形成具有一定嵌段特性的无规共聚物。所述polyzwitterionic共聚物P（MAES X -然-HEMA Ý）（PM X ħ ÿ，其中X和ÿ分别度MAES和HEMA，分别的聚合），这即充当还原和用于覆盖试剂轴承羟基在无需外源添加即可原位合成AgNP。在原位形成的均匀AgNPs复合材料采用典型的“核壳”结构，其中AgNPs作为核，PMH是壳。银离子（Ag ⁺离子）还原过程中，AgNPs核的螯合和PMH上生成的醛可促进AgNPs复合材料的稳定性。与PMH中[MAES]与[HEMA]之比直接相关的AgNPs复合物的尺寸，当PM20H27与AgNO _3的重量比等于30％时，可获得最高的AgNPs复合物产率。通过膜微扰机制，源自PM50H26的AgNPs复合物表现出最强的杀菌活性。此外，通过溶血和细胞毒性测试，证实了AgNPs复合材料对哺乳动物细胞是安全的。