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Functional brain network characteristics are associated with epilepsy severity in childhood absence epilepsy.
NeuroImage: Clinical ( IF 4.2 ) Pub Date : 2020-04-23 , DOI: 10.1016/j.nicl.2020.102264
Gerhard S Drenthen 1 , Floor Fasen 1 , Eric L A Fonseca Wald 2 , Walter H Backes 3 , Albert P Aldenkamp 4 , R Jeroen Vermeulen 5 , Mariette Debeij-van Hall 6 , Jos Hendriksen 6 , Sylvia Klinkenberg 5 , Jacobus F A Jansen 1
Affiliation  

While cognitive impairments are not generally considered to be part of the childhood absence epilepsy (CAE) syndrome, some recent studies report cognitive, mainly attentional, deficits. Here we set out to investigate the whole brain functional network of children with CAE and controls. Furthermore, the possible relation of the functional network abnormalities with epilepsy and neurocognitive characteristics is studied. Seventeen children with childhood CAE (aged 9.2 ± 2.1 years) and 15 controls (aged 9.8 ± 1.8 years) were included. Resting state functional MRI was acquired to study the functional network. Using graph theoretical analysis, three global metrics of the functional network were investigated: the characteristic path length, the clustering coefficient, and the small-worldness. A multivariable linear regression model including age, sex, and subject motion as covariates was used to investigate group differences in the graph metrics. Subsequently, relations of the graph metrics with epilepsy and neurocognitive characteristics were assessed. Longer path lengths, weaker clustering and a lower small-world network topology were observed in children with CAE compared to controls. Moreover, longer path lengths were related to a longer duration of CAE and a higher number of absence seizure per hour. Clustering and small-worldness were not significantly related to epilepsy or neurocognitive characteristics. The organization of the functional network of children with CAE is less efficient compared to controls, and is related to disease duration. These preliminary findings suggest that CAE is associated with alterations in the functional network.

中文翻译:

功能性脑网络特征与儿童缺席癫痫的癫痫严重程度有关。

虽然一般认为认知障碍不是儿童失神癫痫(CAE)综合征的一部分,但最近的一些研究报道了认知缺陷,主要是注意力缺陷。在这里,我们着手研究具有CAE和控制的儿童的整个大脑功能网络。此外,研究了功能网络异常与癫痫和神经认知特征的可能关系。包括17名儿童CAE(9.2±2.1岁)和15名对照(9.8±1.8岁)。获得了静止状态功能MRI以研究功能网络。使用图论分析,研究了功能网络的三个全局度量:特征路径长度,聚类系数和小世界性。多变量线性回归模型,包括年龄,性别,受试者运动作为协变量用于研究图形指标中的组差异。随后,评估了图形指标与癫痫和神经认知特征的关系。与对照组相比,患有CAE的儿童观察到更长的路径长度,更弱的聚类和更低的小世界网络拓扑。而且,更长的路径长度与更长的CAE时间和每小时更高的失神发作次数有关。聚类和小世界与癫痫或神经认知特征无明显关系。与对照组相比,CAE患儿的功能网络的组织效率较低,并且与疾病持续时间有关。这些初步发现表明,CAE与功能网络的改变有关。
更新日期:2020-04-23
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