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Diminished functional properties of T regulatory cells in major depressive disorder: The influence of selective serotonin reuptake inhibitor
Journal of Neuroimmunology ( IF 3.3 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.jneuroim.2020.577250
Leila Jahangard 1 , Mahdi Behzad 2
Affiliation  

The properties of CD4+CD25hi T regulatory cells (Tregs), and interleukin (IL)-2 pathway were investigated in major depressive disorder (MDD) patients treated with or without selective serotonin reuptake inhibitor (SSRI). The frequencies of FOXP3 and pSTAT5 in peripheral Tregs were found to be diminished in untreated patients (SSRI-) versus HCs (p < .001 for both), while their percentages were increased in treated patients (SSRI+) versus untreated patients (p < .001 and p = .04). The proliferation of CD4+ T cells was higher in SSRI-MDD patients versus HCs (p = .03). The SSRI-MDD patients showed a lower concentration of supernatant TGF-β than HCs (p = .001), while the production of TGF-β was enhanced in SSRI+MDD versus SSRI-MDD patients (p = .003). The number of CD45RA-expressing Tregs, the expression of JAK1 and JAK3, and the levels of IL-2 and IL-10 were similar between the patients and HCs. The study results showed that untreated patients have an impaired IL-2 signaling pathway and defective Tregs, and SSRI treatment may improve the Tregs function.

中文翻译:

重度抑郁症中 T 调节细胞的功能特性减弱:选择性 5-羟色胺再摄取抑制剂的影响

在接受或不接受选择性血清素再摄取抑制剂 (SSRI) 治疗的重度抑郁症 (MDD) 患者中研究了 CD4+CD25hi T 调节细胞 (Tregs) 和白细胞介素 (IL)-2 通路的特性。发现外周 Treg 中 FOXP3 和 pSTAT5 的频率在未治疗患者 (SSRI-) 与 HC 中降低(两者 p < .001),而在治疗患者 (SSRI+) 与未治疗患者中其百分比增加 (p < .001)。 001 和 p = .04)。SSRI-MDD 患者的 CD4+ T 细胞增殖高于 HC(p = .03)。SSRI-MDD 患者的上清液 TGF-β 浓度低于 HC(p = .001),而与 SSRI-MDD 患者相比,SSRI+MDD 患者中 TGF-β 的产生增加(p = .003)。表达 CD45RA 的 Tregs 的数量,JAK1 和 JAK3 的表达,并且患者和HC之间的IL-2和IL-10水平相似。研究结果表明,未经治疗的患者存在IL-2信号通路受损和Tregs缺陷,SSRI治疗可能会改善Tregs功能。
更新日期:2020-07-01
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