Neuroaxonal injury and loss result in the release of cytoskeleton components, including neurofilaments, into the cerebrospinal fluid and peripheral blood. Once released, neurofilaments are highly immunogenic, inducing a specific antibody response. Anti-neurofilament antibody levels correlate with the progression of diverse neurological diseases; however, their role both in the pathogenesis of disease and as a tool for monitoring disease progression is not well understood. This study reviews the current literature on anti-neurofilament antibodies. We suggest the testing of anti-neurofilament antibodies be further developed for diagnosis and targeted for treatment.

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抗神经丝抗体和神经变性：标记物和发生器

神经轴突损伤和丢失导致细胞骨架成分（包括神经丝）释放到脑脊液和外周血中。一旦释放，神经丝具有高度免疫原性，诱导特异性抗体反应。抗神经丝抗体水平与多种神经系统疾病的进展相关；然而，它们在疾病发病机制和作为监测疾病进展的工具中的作用尚不清楚。本研究回顾了当前有关抗神经丝抗体的文献。我们建议进一步开发抗神经丝抗体的检测，用于诊断和靶向治疗。