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Pathogenic and antimicrobial resistance genes in Streptococcus oralis strains revealed by comparative genome analysis.
Genomics ( IF 4.4 ) Pub Date : 2020-04-22 , DOI: 10.1016/j.ygeno.2020.04.014
Jiannan Zhou 1 , Tianyong Sun 1 , Wenyan Kang 1 , Di Tang 1 , Qiang Feng 2
Affiliation  

Streptococcus oralis is an early colonizer bacterium in dental plaques and is considered a potential pathogen of infective endocarditis (IE) disease. In this study, we built a complete genome map of Streptococcus oralis strain SOT, Streptococcus oralis strain SOD and Streptococcus infantis strain SO and performed comparative genomic analysis among these three strains. The results showed that there are five genomic islands (GIs) in strain SOT and one CRISPR in strain SOD. Each genome harbors various pathogenic genes related to diseases and drug resistance, while the antibiotic resistance genes in strains SOT and SOD were quite similar but different from those in strain SO. In addition, we identified 17 main virulence factors and capsule-related genes in three strains. These results suggest the pathogenic potential of Streptococcus strains, which lay a foundation for the prevention and treatment of a Streptococcus oralis infection.

中文翻译:

通过比较基因组分析揭示口腔链球菌菌株中的致病基因和抗菌素耐药性基因。

口腔链球菌是牙菌斑中的早期定植细菌,被认为是感染性心内膜炎 (IE) 疾病的潜在病原体。在本研究中,我们构建了口腔链球菌 SOT、口腔链球菌 SOD 和婴儿链球菌 SO 的完整基因组图谱,并对这三种菌株进行了比较基因组分析。结果表明,菌株 SOT 中有 5 个基因组岛 (GIs),菌株 SOD 中有 1 个 CRISPR。每个基因组都包含与疾病和耐药性相关的各种致病基因,而菌株SOT和SOD中的抗生素抗性基因与菌株SO中的抗生素抗性基因非常相似但不同。此外,我们在三个菌株中鉴定了 17 个主要毒力因子和荚膜相关基因。这些结果表明链球菌菌株的致病潜力,
更新日期:2020-04-23
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