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Hepatic toxicological responses of SiO2 nanoparticle on Oreochromis mossambicus.
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-04-21 , DOI: 10.1016/j.etap.2020.103398 P Athif 1 , P Suganthi 1 , M Murali 2 , A Sadiq Bukhari 1 , H E Syed Mohamed 1 , H Basu 3 , R K Singhal 3
中文翻译：
SiO2纳米颗粒对莫桑比克罗非鱼的肝脏毒理反应。
更新日期：2020-04-21
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-04-21 , DOI: 10.1016/j.etap.2020.103398 P Athif 1 , P Suganthi 1 , M Murali 2 , A Sadiq Bukhari 1 , H E Syed Mohamed 1 , H Basu 3 , R K Singhal 3
Affiliation
The present study was carried out to investigate the impact of various concentrations of SiO2 nanoparticles (SiO2 NP) on the commonly available freshwater fish Oreochromis mossambicus. The 96 h median lethal concentration (LC50) of SiO2 NP was found to be between 270−280 ppm. This novel study has demonstrated histological alterations in the hepatic tissues and a dose-dependent depletion of tissue protein content and an elevated transaminases activity in the treated fish, which has facilitated understanding of the impact of SiO2 NP in O. mossambicus.
中文翻译：
SiO2纳米颗粒对莫桑比克罗非鱼的肝脏毒理反应。
本研究旨在研究各种浓度的SiO 2纳米颗粒（SiO 2 NP）对常用淡水鱼Oreochromis mossambicus的影响。发现SiO 2 NP的96 h中位致死浓度（LC 50）在270-280 ppm之间。这项新颖的研究表明，经处理的鱼肝组织发生了组织学改变，组织蛋白质含量呈剂量依赖性消耗，转氨酶活性升高，这有助于人们了解SiO 2 NP对莫桑比克藻的影响。
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