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Alcohol-induced thrombocytopenia: Current review.
Alcohol ( IF 2.3 ) Pub Date : 2020-04-21 , DOI: 10.1016/j.alcohol.2020.02.166
Andrzej Silczuk 1 , Bogusław Habrat 1
Affiliation  

Thrombocytopenia is a decrease in the platelet count below 150,000 in a microliter of blood, i.e., below the lower limit of the reference range, which is 150,000-400,000/μL. The phenomenon of thrombocytopenia related to heavy drinking began to arouse interest in the 1960s and 1970s. It was initially described in case reports and clinical studies on small groups. In the following years, the phenomenon itself and the significance of alcohol-induced thrombocytopenia was studied. Many methodological difficulties inhibiting objective conclusions from research were encountered. Model pathological mechanisms of alcohol thrombocytopenia and the effects of alcohol on the structure and function of platelets were described. Furthermore, the phenomenon of rapid normalization of the number of platelets in people who stopped drinking was described. Relationships between alcohol use, its intensity and occurrence, and intensity of thrombocytopenia have been demonstrated. Predictive platelet counts for alcohol withdrawal syndrome complications have been proven and calculated. The risk of occurrence of withdrawal seizures or delirium tremens in alcohol withdrawal syndrome increases significantly when the platelet count is less than 119,000/μL. The knowledge of the nature of the phenomenon of alcohol-induced thrombocytopenia in a clinical environment allows decisions that are more rational. The attention of clinicians should be drawn to the importance of results of blood tests routinely collected on admission.

中文翻译:

酒精引起的血小板减少症:当前评论。

血小板减少症是指在微升血液中血小板计数减少到150,000以下,即低于参考范围的下限150,000-400,000 /μL。与酗酒有关的血小板减少症现象在1960年代和1970年代开始引起人们的兴趣。最初在病例报告和小组临床研究中对此进行了描述。在接下来的几年中,研究了这种现象本身以及酒精引起的血小板减少症的意义。遇到许多方法上的困难,阻碍了研究的客观结论。描述了酒精性血小板减少症的模型病理机制以及酒精对血小板结构和功能的影响。此外,描述了停止饮酒的人的血小板数量快速正常化的现象。已经证明了饮酒,酒精的强度和发生与血小板减少的强度之间的关系。酒精戒断综合征并发症的预测血小板计数已得到证实和计算。当血小板计数低于119,000 /μL时,戒酒综合征中出现戒断惊厥或del妄的风险显着增加。在临床环境中了解酒精引起的血小板减少现象的性质,可以做出更合理的决策。应提请临床医生注意入院时常规收集的血液检查结果的重要性。酒精戒断综合征并发症的预测血小板计数已得到证实和计算。当血小板计数低于119,000 /μL时,戒酒综合征中出现戒断惊厥或del妄的风险显着增加。在临床环境中了解酒精引起的血小板减少现象的性质,可以做出更合理的决策。应提请临床医生注意入院时常规收集的血液检查结果的重要性。酒精戒断综合征并发症的预测血小板计数已得到证实和计算。当血小板计数低于119,000 /μL时,戒酒综合征中出现戒断惊厥或del妄的风险显着增加。在临床环境中了解酒精引起的血小板减少现象的性质,可以做出更合理的决策。应提请临床医生注意入院时常规收集的血液检查结果的重要性。在临床环境中了解酒精引起的血小板减少现象的性质,可以做出更合理的决策。应提请临床医生注意入院时常规收集的血液检查结果的重要性。在临床环境中了解酒精引起的血小板减少现象的性质,可以做出更合理的决策。应提请临床医生注意入院时常规收集的血液检查结果的重要性。
更新日期:2020-04-21
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